Inhibition of the cGAS‐STING pathway ameliorates the premature senescence hallmarks of Ataxia‐Telangiectasia brain organoids

Aging Cell

Harman K. Chaggar¹  Julio Aguado¹  Cecilia Gómez‐Inclán¹  Ernst J. Wolvetang¹  Hannah C. Leeson¹  Mohammed R. Shaker¹  Alan Mackay‐Sim² 

[1] Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Saint Lucia, Queensland, Australia;Department of Neurogenetics, Kolling Institute, Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia;Griffith Institute for Drug Discovery, Griffith University, Nathan, Queensland, Australia;

关键词: Ataxia‐Telangiectasia;    brain aging;    brain organoids;    cGAS‐STING signalling;    cellular senescence;    neurodegeneration;   

DOI  :  10.1111/acel.13468

来源: Wiley

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