miR‐24 and its target gene Prdx6 regulate viability and senescence of myogenic progenitors during aging

Aging Cell

Brian McDonagh¹  Qin Xia¹  Rachel McCormick²  Ana Soriano‐Arroquia²  Peter Clegg²  David Bardell²  Katarzyna Goljanek‐Whysall³  Ilaria Bellantuono⁴  Eugene McCloskey⁴  John Gostage⁵ 

[1] Discipline of Physiology, School of Medicine, National University of Ireland, Galway, Ireland;Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, UK;The Medical Research Council/Versus Arthritis Centre for Integrated Research into Musculoskeletal Aging, CIMA, University of Liverpool, Liverpool, UK;Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, UK;The Medical Research Council/Versus Arthritis Centre for Integrated Research into Musculoskeletal Aging, CIMA, University of Liverpool, Liverpool, UK;Discipline of Physiology, School of Medicine, National University of Ireland, Galway, Ireland;The Medical Research Council/Versus Arthritis Centre for Integrated Research into Musculoskeletal Aging, CIMA, University of Liverpool, Liverpool, UK;Department of Oncology and Metabolism, Healthy Lifespan Institute and the Centre for Integrated Research in Musculoskeletal Aging, University of Sheffield, Sheffield, UK;The Medical Research Council/Versus Arthritis Centre for Integrated Research into Musculoskeletal Aging, CIMA, University of Liverpool, Liverpool, UK;Discipline of Physiology, School of Medicine, National University of Ireland, Galway, Ireland;Department of Oncology and Metabolism, Healthy Lifespan Institute and the Centre for Integrated Research in Musculoskeletal Aging, University of Sheffield, Sheffield, UK;

关键词: aging;    miR‐24;    muscle regeneration;    oxidative stress;    Prdx6;    satellite cells;    senescence;   

DOI  :  10.1111/acel.13475

来源: Wiley

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