Diagnostics and correction of batch effects in large‐scale proteomic studies: a tutorial

Molecular Systems Biology

Tatjana Sajic¹  Varun S Sharma¹  Chloe H Lee¹  Patrick G A Pedrioli²  Ruedi Aebersold³  Evan G Williams⁴  Jelena Čuklina⁵  Ben C Collins⁶  Fabian Wendt⁷  Sandra Goetze⁸  Bernd Wollscheid⁸  María Rodríguez Martínez⁹  Gregory R Keele^1,10 

[1] Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland;Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland;Department of Health Sciences and Technology, Institute of Translational Medicine, ETH Zurich, Zurich, Switzerland;ETH Zürich, PHRT‐CPAC, Zürich, Switzerland;SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland;Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland;Faculty of Science, University of Zurich, Zurich, Switzerland;Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland;Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Luxembourg, Luxembourg;Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland;PhD Program in Systems Biology, University of Zurich and ETH Zurich, Zurich, Switzerland;IBM Research Europe, Rüschlikon, Switzerland;Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland;Queen’s University Belfast, Belfast, UK;Department of Health Sciences and Technology, Institute of Translational Medicine, ETH Zurich, Zurich, Switzerland;Department of Health Sciences and Technology, Institute of Translational Medicine, ETH Zurich, Zurich, Switzerland;ETH Zürich, PHRT‐CPAC, Zürich, Switzerland;SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland;IBM Research Europe, Rüschlikon, Switzerland;The Jackson Laboratory, Bar Harbor, ME, USA;

关键词: batch effects;    data analysis;    large‐scale proteomics;    normalization;    quantitative proteomics;   

DOI  :  10.15252/msb.202110240

来源: Wiley

【 授权许可】

CC BY