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EMBO Molecular Medicine
The immune suppressive microenvironment affects efficacy of radio‐immunotherapy in brain metastasis
Franz Rödel1  Timm Oberwahrenbrock2  Aylin Möckl3  Stefan Stein3  Katja Niesel3  Tijna Alekseeva3  Marco Lolies3  Julian Anthes3  Michael Schulz4  Anna Salamero‐Boix4  Lisa Sevenich5  Jadranka Macas6  Yvonne Reiss7  Karl H Plate7 
[1] Frankfurt Cancer Institute (FCI), Goethe University Frankfurt, Frankfurt am Main, Germany;German Cancer Consortium (DKTK), Partner Site Frankfurt/Mainz, Germany and German Cancer Research Center (DKFZ), Heidelberg, Germany;Department of Radiotherapy and Oncology, Goethe University Frankfurt, Frankfurt am Main, Germany;Fraunhofer Institute for Translational Medicine and Pharmacology (ITMP), Frankfurt am Main, Germany;Fraunhofer Cluster of Excellence Immune Mediated Diseases (CIMD), Frankfurt am Main, Germany;Institute for Tumor Biology and Experimental Therapy, Georg‐Speyer‐Haus, Frankfurt am Main, Germany;Institute for Tumor Biology and Experimental Therapy, Georg‐Speyer‐Haus, Frankfurt am Main, Germany;Biological Sciences, Faculty 15, Goethe University Frankfurt, Frankfurt am Main, Germany;Institute for Tumor Biology and Experimental Therapy, Georg‐Speyer‐Haus, Frankfurt am Main, Germany;Frankfurt Cancer Institute (FCI), Goethe University Frankfurt, Frankfurt am Main, Germany;German Cancer Consortium (DKTK), Partner Site Frankfurt/Mainz, Germany and German Cancer Research Center (DKFZ), Heidelberg, Germany;Institute of Neurology (Edinger Institute), University Hospital, Goethe University, Frankfurt am Main, Germany;Frankfurt Cancer Institute (FCI), Goethe University Frankfurt, Frankfurt am Main, Germany;Institute of Neurology (Edinger Institute), University Hospital, Goethe University, Frankfurt am Main, Germany;Frankfurt Cancer Institute (FCI), Goethe University Frankfurt, Frankfurt am Main, Germany;German Cancer Consortium (DKTK), Partner Site Frankfurt/Mainz, Germany and German Cancer Research Center (DKFZ), Heidelberg, Germany;
关键词: brain cancer;    checkpoint inhibitors;    microglia;    tumor microenvironment;    tumor‐associated macrophages;   
DOI  :  10.15252/emmm.202013412
来源: Wiley
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