Pseudolaric acid B ameliorates synovial inflammation and vessel formation by stabilizing PPARγ to inhibit NF‐κB signalling pathway

Journal of Cellular and Molecular Medicine

Dan Wu¹  Huaji Jiang¹  Hongyu Li¹  Zhiqiang Hu¹  Ke Zeng¹  Xiao Yu²  Jiansen Lu³  Chenglong Pan⁴  Haiyan Zhang⁵  Hongbo Zhang⁵  Daozhang Cai⁵  Hong Guan⁵  Jingyao Yu⁶ 

[1] Department of Immunology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China;Department of Immunology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China;Department of Joint Surgery, the Fifth Affiliated Hospital of Southern Medical University Guangdong Province, Guangzhou, China;Guangdong Provincial Key Lab of Single Cell Technology and Application, Southern Medical University, Guangzhou, China;Department of Immunology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China;Department of Orthopedics, Orthopedic Hospital of Guangdong Province, Academy of Orthopedics·Guangdong Province, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China;Department of Joint Surgery, the Fifth Affiliated Hospital of Southern Medical University Guangdong Province, Guangzhou, China;Department of Joint Surgery, the Fifth Affiliated Hospital of Southern Medical University Guangdong Province, Guangzhou, China;Department of Orthopedics, Orthopedic Hospital of Guangdong Province, Academy of Orthopedics·Guangdong Province, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China;The Third School of Clinical Medicine, Southern Medical University, Guangzhou, China;Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, Guangzhou, China;Department of Joint Surgery, Center for Orthopaedic Surgery, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China;School of Basic Medical Sciences, Gannan Medical University, Ganzhou, China;

关键词: NF‐κB signalling;    Osteoarthritis;    PPARγ;    pseudolaric acid B;   

DOI  :  10.1111/jcmm.16670

来源: Wiley

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