Loss of glucocorticoid rhythm induces an osteoporotic phenotype in female mice

Aging Cell

Leo van Ruijven¹  Alberto M. Pereira²  Natasha M. Appelman‐Dijkstra³  Nathalie Bravenboer⁴  Annelies E. Smit⁵  Sander Kooijman⁵  Onno C. Meijer⁵  Patrick C.N. Rensen⁵  Max Gentenaar⁵  Maaike Schilperoort⁵  Jan Kroon⁵  Elizabeth M. Winter⁶  Björn Busse⁷  Kathrin Mletzko⁷  Felix N. Schmidt⁷ 

[1] Department of Functional Anatomy, Academic Center for Dentistry Amsterdam (ACTA), Amsterdam, The Netherlands;Department of Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands;Department of Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands;Department of Medicine, Center for Bone Quality, Leiden University Medical Center, Leiden, The Netherlands;Department of Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands;Department of Medicine, Center for Bone Quality, Leiden University Medical Center, Leiden, The Netherlands;Department of Clinical Chemistry, Vrije Universiteit Amsterdam, Amsterdam Movement Sciences, Amsterdam, The Netherlands;Department of Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands;Einthoven Laboratory for Experimental Vascular Medicine, Leiden, The Netherlands;Department of Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands;Einthoven Laboratory for Experimental Vascular Medicine, Leiden, The Netherlands;Department of Medicine, Center for Bone Quality, Leiden University Medical Center, Leiden, The Netherlands;Department of Osteology and Biomechanics (IOBM), University Medical Center Hamburg‐Eppendorf, Hamburg, Germany;

关键词: bone health;    circadian rhythm;    corticosteroids;    fracture risk;    osteoporosis;   

DOI  :  10.1111/acel.13474

来源: Wiley

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CC BY