Pro‐inflammatory signals induce 20α‐HSD expression in myometrial cells: A key mechanism for local progesterone withdrawal

Journal of Cellular and Molecular Medicine

Sam Mesiano¹  Lubna Nadeem²  Rathesh Balendran²  Anna Dorogin²  Oksana Shynlova³  Stephen J. Lye³ 

[1] Department of Reproductive Biology, Case Western Reserve University, Cleveland, OH, USA;Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada;Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada;Department of Physiology, University of Toronto, Toronto, ON, Canada;Department of Obstetrics & Gynecology, University of Toronto, Toronto, ON, Canada;

关键词: 20α‐HSD;    AP‐1;    labour;    myometrium;    NF‐кB;    preterm birth;    progesterone metabolism;   

DOI  :  10.1111/jcmm.16681

来源: Wiley

【 授权许可】

CC BY