NUDT15 polymorphism and NT5C2 and PRPS1 mutations influence thiopurine sensitivity in acute lymphoblastic leukaemia cells

Journal of Cellular and Molecular Medicine

Yoichi Tanaka¹  Junko Takita²  Shotaro Iwamoto³  Minori Tamai⁴  Kanji Sugita⁴  Masako Abe⁴  Koshi Akahane⁴  Shinpei Somazu⁴  Kumiko Goi⁴  Takeshi Inukai⁴  Daisuke Harama⁴  Tamao Shinohara⁴  Atsushi Watanabe⁴  Keiko Kagami⁴  Jun Yang⁵  Takaya Moriyama⁵  Hiroaki Goto⁶  Masayoshi Minegishi⁷ 

[1] Department of Clinical Pharmacy, Center for Clinical Pharmacy and Sciences, School of Pharmacy, Kitasato University, Minato‐ku, Japan;Department of Pediatrics, Kyoto University, Kyoto, Japan;Department of Pediatrics, Mie University Graduate School of Medicine, Tsu, Japan;Department of Pediatrics, University of Yamanashi, Yamanashi, Japan;Department of Pharmaceutical Sciences, St Jude Children's Research Hospital, Memphis, Tennessee, USA;Division of Hematology/Oncology, Kanagawa Children's Medical Center, Kanagawa, Japan;Tohoku Block Center, Japanese Red Cross Society, Sendai, Japan;

关键词: acute lymphoblastic leukemia;    maintenance therapy;    mercaputopurine;    pharmacogenetics;   

DOI  :  10.1111/jcmm.16981

来源: Wiley

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