Reduced amyloid‐β degradation in early Alzheimer's disease but not in the APPswePS1dE9 and 3xTg‐AD mouse models

Aging Cell

Lieneke Kooijman¹  Willem Kamphuis¹  Elly M. Hol²  Marcel Raspe³  Judith Gillis³  Anita Stargardt³  Eric Reits³  Anne Wiemhoefer³  Willemien Benckhuijsen⁴  Jan W. Drijfhout⁴ 

[1] Department of Astrocyte Biology and Neurodegeneration, Netherlands Institute for Neuroscience – an Institute of the Royal Netherlands Academy of Arts and Sciences (KNAW), Meibergdreef 47, 1105 BA Amsterdam, The Netherlands;Department of Astrocyte Biology and Neurodegeneration, Netherlands Institute for Neuroscience – an Institute of the Royal Netherlands Academy of Arts and Sciences (KNAW), Meibergdreef 47, 1105 BA Amsterdam, The Netherlands;Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, Sciencepark 904 1098 XH Amsterdam, The Netherlands;Department of Cell Biology and Histology, Academic Medical Center, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands;Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands;

关键词: APP;    A;    amyloid;    insulin‐degrading enzyme;    AD;   

DOI  :  10.1111/acel.12074

来源: Wiley

【 授权许可】

Unknown