An integrative systems approach identifies novel candidates in Marfan syndrome‐related pathophysiology

Journal of Cellular and Molecular Medicine

Lukas Altinbas¹  Daniel Lehmann¹  Marten Jäger²  Georgios Kararigas³  Peter N. Robinson⁴  Raghu Bhushan⁵  Marcin Zaradzki⁶  Klaus Kallenbach⁷  Bernd Timmermann⁸  Yunxiang Zhu⁹  Nicholas P. Clayton⁹ 

[1]Charité University Hospital, Berlin, Germany

[2]Charité University Hospital, Berlin, Germany

[3]Berlin Institute of Health (BIH) Core Genomics Facility, Charité, University Medical Center, Berlin, Germany

[4]Charité University Hospital, Berlin, Germany

[5]DZHK (German Centre for Cardiovascular Research), Berlin, Germany

[6]Charité University Hospital, Berlin, Germany

[7]Max Planck Institute for Molecular Genetics, Berlin, Germany

[8]The Jackson Laboratory for Genomic Medicine, Farmington, Connecticut

[9]Charité University Hospital, Berlin, Germany

[10]Yenepoya Research Centre, Yenepoya (Deemed to be University), Deralakatte, Mangalore, India

[11]Department of Cardiac Surgery, University Hospital Heidelberg, Heidelberg, Germany

[12]Department of Cardiac Surgery, University Hospital Heidelberg, Heidelberg, Germany

[13]Department of Cardiac Surgery, INCCI HaerzZenter, Luxembourg, Luxembourg

[14]Max Planck Institute for Molecular Genetics, Berlin, Germany

[15]Sanofi Genzyme, Framingham, Massachusetts

关键词: Chemokine signalling;    Igfbp2 signalling;    Marfan syndrome;    Mfap4;    mgR/mgR;    RNA;    Spp1;    TGF;    Transcriptomics;   

DOI  :  10.1111/jcmm.14137

来源: Wiley

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CC BY