Nanog maintains stemness of Lkb1‐deficient lung adenocarcinoma and prevents gastric differentiation

EMBO Molecular Medicine

Lei Xiao¹  Rui Wang²  Haiquan Chen²  Xinsheng Zhu³  Peng Zhang³  Yi Ye⁴  Wenjing Zhang⁵  Xinyuan Tong⁵  Yijun Gao⁵  Yun Xue⁶  Yueqing Chen⁶  Hongbin Ji⁷  Weiqiang Gao⁸ 

[1] College of Animal Science and Zhejiang University School of Medicine, Zhejiang University, Hangzhou, China;Department of Thoracic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China;Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China;Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China;School of Life Science and Technology, Shanghai Tech University, Shanghai, China;State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, China;State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, China;University of Chinese Academy of Sciences, Beijing, China;State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, China;University of Chinese Academy of Sciences, Beijing, China;Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China;School of Life Science and Technology, Shanghai Tech University, Shanghai, China;State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;Med‐X Research Institute, Shanghai Jiao Tong University, Shanghai, China;

关键词: drug resistance;    gastric differentiation;    LKB1;    Nanog;    Notch;   

DOI  :  10.15252/emmm.202012627

来源: Wiley

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