DNA methylation signatures of incident coronary heart disease: findings from epigenome-wide association studies

Clinical Epigenetics

Yujing Xia¹  Jordana T. Bell¹  Alison Brewer² 

[1] Department of Twin Research and Genetic Epidemiology, Kings College London, SE1 7EH, London, UK;School of Cardiovascular Medicine and Sciences, James Black Centre, King’s College London British Heart Foundation Centre of Excellence, 125 Coldharbour Lane, SE5 9NU, London, UK;

关键词: DNA methylation;    Incident coronary heart disease;    Epigenome-wide association study;   

DOI  :  10.1186/s13148-021-01175-6

来源: Springer

【 摘 要 】

Coronary heart disease (CHD) is a type of cardiovascular disease (CVD) that affects the coronary arteries, which provide oxygenated blood to the heart. It is a major cause of mortality worldwide. Various prediction methods have been developed to assess the likelihood of developing CHD, including those based on clinical features and genetic variation. Recent epigenome-wide studies have identified DNA methylation signatures associated with the development of CHD, indicating that DNA methylation may play a role in predicting future CHD. This narrative review summarises recent findings from DNA methylation studies of incident CHD (iCHD) events from epigenome-wide association studies (EWASs). The results suggest that DNA methylation signatures may identify new mechanisms involved in CHD progression and could prove a useful adjunct for the prediction of future CHD.

【 授权许可】

CC BY