Determination of the Optimal Cutoff Value of Triglyceride That Corresponds to Fasting Levels in Chinese Subjects With Marked Hypertriglyceridemia

Frontiers in Cardiovascular Medicine

Zhe-Yi Jiang¹  Li-Ling Guo²  Yang-Rong Tan²  Ying-Ying Xie²  Qun-Yan Xiang²  Ling Liu²  Jin Xu²  Li-Yuan Zhu² 

[1] Clinical Nursing Teaching and Research Section, The Second Xiangya Hospital, Central South University, Changsha, China;Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha, China;Research institute of Blood Lipid and Atherosclerosis, Center South University, Changsha, China;Modern Cardiovascular Disease Clinical Technology Research Center of Hunan Province, Changsha, China;Cardiovascular Disease Research Center of Hunan Province, Changsha, China;

关键词: triglyceride;    marked hypertriglyceridemia;    postprandial;    cut-off value;    daily meal;   

DOI  :  10.3389/fcvm.2021.736059

来源: Frontiers

【 摘 要 】

The level of triglyceride (TG) ≥ 2. 3 mmol/L is suggestive of marked hypertriglyceridemia (HTG) and requires treatment with a triglyceride-lowering agent in high-risk and very high-risk patients as recommended by the 2019 ESC/EAS guidelines for the management of dyslipidemia. However, the optimal cutoff value required to diagnose non-fasting HTG that corresponds to the fasting goal level of 2.3 mmol/L in Chinese subjects is unknown. This study enrolled 602 cardiology inpatients. Blood lipid levels, including calculated non-high-density lipoprotein cholesterol (non-HDL-C) and remnant cholesterol (RC), were measured at 0, 2, and 4 h after a daily Chinese breakfast. Of these, 482 inpatients had TG levels of <2.3 mmol/L (CON group) and 120 inpatients had TG levels of ≥2.3 mmol/L (HTG group). Receiver operating characteristic (ROC) curve analysis was used to determine the cutoff values for postprandial HTG that corresponded to a target fasting level of 2.3 mmol/L. Marked hypertriglyceridemia (≥2.3 mmol/L) was found in 120 (19.9%) patients in this study population. The levels of non-fasting TG and RC increased significantly in both groups and reached the peak at 4 h after a daily meal, especially in the HTG group (p < 0.05). The optimal cutoff value of TG at 4 h, which corresponds to fasting TG of ≥2.3 mmol/L, that can be used to predict HTG, was 2.66 mmol/L. According to the new non-fasting cutoff value, the incidence of non-fasting HTG is close to its fasting level. In summary, this is the first study to determine the non-fasting cutoff value that corresponds to a fasting TG of ≥2.3 mmol/L in Chinese patients. Additionally, 2.66 mmol/l at 4 h after a daily meal could be an appropriate cutoff value that can be used to detect non-fasting marked HTG in Chinese subjects.

【 授权许可】

CC BY