Evolutionary dynamics of circular RNAs in primates

eLife

Robert J Weatheritt¹  Gabriela Santos-Rodriguez¹  Irina Voineagu² 

[1] EMBL Australia, Garvan Institute of Medical Research, Darlinghurst, Australia;St. Vincent Clinical School, University of New South Wales, Darlinghurst, Australia;School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, Australia;

关键词: circRNA;    comparative genomics;    RNA;    evolution;    non-coding RNAs;    Human;    Rhesus macaque;    Other;   

DOI  :  10.7554/eLife.69148

来源: eLife Sciences Publications, Ltd

【 摘 要 】

Many primate genes produce circular RNAs (circRNAs). However, the extent of circRNA conservation between closely related species remains unclear. By comparing tissue-specific transcriptomes across over 70 million years of primate evolution, we identify that within 3 million years circRNA expression profiles diverged such that they are more related to species identity than organ type. However, our analysis also revealed a subset of circRNAs with conserved neural expression across tens of millions of years of evolution. By comparing to species-specific circRNAs, we identified that the downstream intron of the conserved circRNAs display a dramatic lengthening during evolution due to the insertion of novel retrotransposons. Our work provides comparative analyses of the mechanisms promoting circRNAs to generate increased transcriptomic complexity in primates.

【 授权许可】

CC BY