Auditory sensory deprivation induced by noise exposure exacerbates cognitive decline in a mouse model of Alzheimer’s disease

eLife

Marco Rinaudo¹  Sara Cocco¹  Giulia Conforto¹  Valentina Longo¹  Anna Pisani²  Maria Vittoria Podda³  Fabiola Paciello³  Claudio Grassi³  Gaetano Paludetti⁴  Anna Rita Fetoni⁴ 

[1] Department of Neuroscience, Università Cattolica del Sacro Cuore, Rome, Italy;Department of Otolaryngology Head and Neck Surgery, Università Cattolica del Sacro Cuore, Rome, Italy;Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy;Department of Neuroscience, Università Cattolica del Sacro Cuore, Rome, Italy;Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy;Department of Otolaryngology Head and Neck Surgery, Università Cattolica del Sacro Cuore, Rome, Italy;

关键词: hearing loss;    dementia;    oxidative stress;    tau phosphorylation;    neuroinflammation;    Mouse;   

DOI  :  10.7554/eLife.70908

来源: eLife Sciences Publications, Ltd

【 摘 要 】

Although association between hearing impairment and dementia has been widely documented by epidemiological studies, the role of auditory sensory deprivation in cognitive decline remains to be fully understood. To address this issue we investigated the impact of hearing loss on the onset and time-course of cognitive decline in an animal model of Alzheimer’s disease (AD), that is the 3×Tg-AD mice and the underlying mechanisms. We found that hearing loss induced by noise exposure in the 3×Tg-AD mice before the phenotype is manifested caused persistent synaptic and morphological alterations in the auditory cortex. This was associated with earlier hippocampal dysfunction, increased tau phosphorylation, neuroinflammation, and redox imbalance, along with anticipated memory deficits compared to the expected time-course of the neurodegenerative phenotype. Our data suggest that a mouse model of AD is more vulnerable to central damage induced by hearing loss and shows reduced ability to counteract noise-induced detrimental effects, which accelerates the neurodegenerative disease onset.

【 授权许可】

CC BY