Stimulus-specific plasticity in human visual gamma-band activity and functional connectivity

eLife

Heike Schuler¹  Alina Peter²  Benjamin J Stauch³  Pascal Fries⁴ 

[1] Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, Frankfurt, Germany;Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, Frankfurt, Germany;International Max Planck Research School for Neural Circuits, Frankfurt, Germany;Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, Frankfurt, Germany;International Max Planck Research School for Neural Circuits, Frankfurt, Germany;Brain Imaging Center, Goethe University Frankfurt, Frankfurt, Germany;Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, Frankfurt, Germany;International Max Planck Research School for Neural Circuits, Frankfurt, Germany;Brain Imaging Center, Goethe University Frankfurt, Frankfurt, Germany;Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, Netherlands;

关键词: gamma oscillations;    repetition suppression;    early visual cortex;    stimulus repetition;    MEG;    Human;   

DOI  :  10.7554/eLife.68240

来源: eLife Sciences Publications, Ltd

【 摘 要 】

Under natural conditions, the visual system often sees a given input repeatedly. This provides an opportunity to optimize processing of the repeated stimuli. Stimulus repetition has been shown to strongly modulate neuronal-gamma band synchronization, yet crucial questions remained open. Here we used magnetoencephalography in 30 human subjects and find that gamma decreases across ≈10 repetitions and then increases across further repetitions, revealing plastic changes of the activated neuronal circuits. Crucially, increases induced by one stimulus did not affect responses to other stimuli, demonstrating stimulus specificity. Changes partially persisted when the inducing stimulus was repeated after 25 minutes of intervening stimuli. They were strongest in early visual cortex and increased interareal feedforward influences. Our results suggest that early visual cortex gamma synchronization enables adaptive neuronal processing of recurring stimuli. These and previously reported changes might be due to an interaction of oscillatory dynamics with established synaptic plasticity mechanisms.

【 授权许可】

CC BY