Identification of neural progenitor cells and their progeny reveals long distance migration in the developing octopus brain

eLife

Gregory E Maes¹  Astrid Deryckere²  Eve Seuntjens²  Ali Murat Elagoz²  Ruth Styfhals³ 

[1] Center for Human Genetics, Genomics Core, UZ-KU Leuven, Leuven, Belgium;Centre for Sustainable Tropical Fisheries and Aquaculture, College of Science and Engineering, James Cook University, Townsville, Australia;Laboratory of Biodiversity and Evolutionary Genomics, Department of Biology, KU Leuven, Leuven, Belgium;Laboratory of Developmental Neurobiology, Department of Biology, KU Leuven, Leuven, Belgium;Laboratory of Developmental Neurobiology, Department of Biology, KU Leuven, Leuven, Belgium;Department of Biology and Evolution of Marine Organisms, Stazione Zoologica Anton Dohrn, Naples, Italy;

关键词: octopus vulgaris;    neuronal migration;    neurogenesis;    transcription factors;    brain development;    Other;   

DOI  :  10.7554/eLife.69161

来源: eLife Sciences Publications, Ltd

【 摘 要 】

Cephalopods have evolved nervous systems that parallel the complexity of mammalian brains in terms of neuronal numbers and richness in behavioral output. How the cephalopod brain develops has only been described at the morphological level, and it remains unclear where the progenitor cells are located and what molecular factors drive neurogenesis. Using histological techniques, we located dividing cells, neural progenitors and postmitotic neurons in Octopus vulgaris embryos. Our results indicate that an important pool of progenitors, expressing the conserved bHLH transcription factors achaete-scute or neurogenin, is located outside the central brain cords in the lateral lips adjacent to the eyes, suggesting that newly formed neurons migrate into the cords. Lineage-tracing experiments then showed that progenitors, depending on their location in the lateral lips, generate neurons for the different lobes, similar to the squid Doryteuthis pealeii. The finding that octopus newborn neurons migrate over long distances is reminiscent of vertebrate neurogenesis and suggests it might be a fundamental strategy for large brain development.

【 授权许可】

CC BY