Histopathological, immunohistochemical and molecular biologic study of an enucleated specimen of a case of Eales’ disease

Journal of Ophthalmic Inflammation and Infection

Radhika Mhatre¹  Anita Mahadevan¹  Dipankar Das²  M. K. Janani³  Sneha Giridhar⁴  Gazal Patnaik⁵  Jyotirmay Biswas⁵  Amravi Shah⁵ 

[1] Department of Neuropathology, NIMHANS, Bengaluru, Karnataka, India;Department of Uvea, Sri SankaradevaNethralaya, Guwahati, Assam, India;Sankara Nethralaya Referral Laboratory, Chennai, Tamil Nadu, India;Shri BhagwanMahavir Vitreoretinal Services Sankara Nethralaya, 18 College Road, Chennai, Tamilnadu, India;Uvea Department, Medical Research Foundation, Sankara Nethralaya, 18 College Road, 600006, Chennai, Tamilnadu, India;

关键词: Eales’;    Immunohistochemistry;    PCR;    Retinal;    Vasculitis;   

DOI  :  10.1186/s12348-021-00259-x

来源: Springer

【 摘 要 】

Eales’ disease is a retinal vasculitis characterized by retinal inflammation, ischemia, and neovascularization. Exact pathogenesis of this disease is yet to be found out. We present a 29-year-old male, diagnosed with Eales’ disease in both eyes with persistent intraocular inflammation. Enucleation of the pthisical right eye was subjected for histopathological examination immunohistochemistry and molecular biologic study for mycobacterial tuberculosis DNA. Our study showed that Eales disease is probably a T cell mediated disease which is triggered by mycobacterial TB DNA. Further studies are needed to confirm our findings.

【 授权许可】

CC BY