Clinical value of baseline 18F-FDG PET/CT in soft tissue sarcomas

European Journal of Hybrid Imaging

Guadalupe Ruiz Merino¹  José Fulgencio Contreras Gutiérrez²  Laura Frutos Esteban²  Laroussi Mohamed Salem²  María Isabel Castellón Sánchez²  María Antonia Claver Valderas²  José Luis Navarro Fernández²  Rafael Hernando Reyes Marlés³  José Pablo Puertas García-Sandoval⁴  Fernando Santonja Medina⁴ 

[1] Data Analytics Department, Instituto Murciano de Investigación Biosanitaria (IMIB) Virgen de la Arrixaca, El Palmar, Murcia, Spain;Nuclear Medicine Department, Hospital Clínico Universitario Virgen de la Arrixaca, El Palmar, Murcia, Spain;Nuclear Medicine Division (DIMEC), Hospitales Universitarios San Roque, Las Palmas de Gran Canaria, Las Palmas, Spain;Nuclear Medicine Department, Hospital Clínico Universitario Virgen de la Arrixaca, El Palmar, Murcia, Spain;Orthopedics and Traumatology Department, Hospital Clínico Universitario Virgen de la Arrixaca, El Palmar, Murcia, Spain;

关键词: FDG;    PET/CT;    SUV;    MTV;    TLG;    FNCLCC;    Soft tissue sarcomas;   

DOI  :  10.1186/s41824-021-00110-5

来源: Springer

【 摘 要 】

BackgroundThe use of 18F-FDG Positron emission tomography/Computed tomography (PET/CT) in the initial staging of many cancers is clearly established. Most soft tissue sarcoma (STS) has a high affinity for 18F-FDG, which is why 18F-FDG PET/CT has been proposed as a non-invasive method, useful in diagnosis and follow-up. The standardized uptake value values (SUV), the volume-based metabolic parameters MTV (metabolic tumor volume), and TLG (total lesion glycolysis) determine tumor viability and provide its total volume and the total activity of metabolically active tumor cells. The histological grade is the most important predictor of metastases and mortality associated with STS, and a significant relationship between the metabolic parameters of 18F-FDG PET/CT and the histological grade has been described.MethodsA retrospective study was conducted on STS patients, who had histological grade according to the FNCLCC (Fédération Nationale des Centres de Lutte Contre Le Cancer) criteria, as well as a baseline PET/CT. SUV (SUVmax, SUVmean, and SUVpeak), MTV, and TLG were quantified. A T-student test was performed to establish the relationship between the metabolic biomarkers and the histological grade. Their usefulness as predictors of the histological grade was verified using receiver operator characteristic (ROC) curves. A survival function study was performed using the Kaplan–Meier method. To assess the prognostic utility of the metabolic biomarkers we use the Log-Rank method.ResultsThe SUV values were useful to discriminate high-grade STS. We found a significant relationship between the histological grade and the SUV values. SUVmax, SUVpeak, MTV, and TLG were predictors of overall survival (OS). There were no significant differences in the OS for the SUVmean, or in the disease-free survival (DFS) for SUVmax, SUVmean, SUVpeak, MTV, and TLG.ConclusionsThe SUVmax, SUVmean, and SUVpeak values correlate with the HG and are useful to discriminate high-grade from low-grade STS. Patients with high SUVmax, SUVpeak, MTV, and TLG have a significantly lower OS.

【 授权许可】

CC BY