Hsa_circ_0004712 downregulation attenuates ovarian cancer malignant development by targeting the miR-331-3p/FZD4 pathway

Journal of Ovarian Research

Jinchi Jiang¹  Xuan Zhou²  Shuaishuai Guo² 

[1] Department of Radiology, Shenyang Women’s and Children’s Hospital, Shenyang, Liaoning, China;Reproductive Medicine Center, Shenyang Women’s and Children’s Hospital, No. 87 Danan Street, Shenhe District, 110000, Shenyang, Liaoning, China;

关键词: hsa_circ_0004712;    miR-331-3p;    FZD4;    Ovarian cancer;   

DOI  :  10.1186/s13048-021-00859-0

来源: Springer

【 摘 要 】

BackgroundCircular RNAs (circRNAs) are gradually reported to be implicated in the development of malignant tumors, including ovarian cancer (OC). This paper intended to explore the function and action mechanism of hsa_circ_0004712 in OC.ResultsIn our results, hsa_circ_0004712 was aberrantly overexpressed in OC tissues and cells. Downregulation of hsa_circ_0004712 impaired OC cell proliferation, colony formation, invasion and migration, and accelerated apoptosis. Hsa_circ_0004712 directly targeted miR-331-3p whose inhibitors reversed the effects of hsa_circ_0004712 downregulation. FZD4 was targeted by miR-331-3p, and hsa_circ_0004712 could positively regulated FZD4 expression by targeting miR-331-3p. The anti-tumor effects of miR-331-3p restoration were reversed by FZD4 overexpression. Downregulation of hsa_circ_0004712 also impaired tumor development in vivo by regulating miR-331-3p and FZD4.ConclusionIn conclusion, hsa_circ_0004712 deficiency repressed OC development by mediating the miR-331-3p/FZD4 pathway, predicting that hsa_circ_0004712 was a promising biomarker for OC diagnosis and therapy.

【 授权许可】

CC BY