Pharmacokinetics of loxoprofen in a self-administered overdose in a Japanese patient admitted to hospital

Journal of Pharmaceutical Health Care and Sciences

Kosuke Yoshida¹  Ryo Unita¹  Yuki Sugitani¹  Mariko Terashima¹  Satoru Beppu¹  Masaya Fujii²  Makiko Shimizu²  Hiroshi Yamazaki²  Koichiro Adachi³ 

[1] Kyoto Medical Center, Fushimi-ku, 612-8555, Kyoto, Japan;Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, 3-3165 Higashi-tamagawa Gakuen, Machida, 194-8543, Tokyo, Japan;Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, 3-3165 Higashi-tamagawa Gakuen, Machida, 194-8543, Tokyo, Japan;Kyoto Medical Center, Fushimi-ku, 612-8555, Kyoto, Japan;Present address, Himeji Medical Center, 670-8520, Himeji, Hyogo, Japan;

关键词: Pharmacokinetic modeling;    Overdose;    Absorption;    Elimination;   

DOI  :  10.1186/s40780-021-00216-9

来源: Springer

【 摘 要 】

BackgroundLoxoprofen is a propionic acid derivative and is the most widely prescribed non-steroidal anti-inflammatory drug in Japan. Loxoprofen is generally considered to be relatively nontoxic.Case presentationA 33-year-old man (body weight, 55 kg) who intentionally took an overdose of 100 tablets of loxoprofen (6000 mg) as a suicide attempt was emergently admitted to Kyoto Medical Center. On arrival, the patient was suffering disorders of consciousness. His plasma concentrations of loxoprofen and its reduced trans-alcohol metabolite were 52 and 24 μg/mL, 3.7 and 2.3 μg/mL, 0.81 and 0.54 μg/mL, and 0.015 and 0.011 μg/mL, respectively, at 4, 26, 50, and 121 h after the oral overdose. The observed apparent terminal elimination half-life of loxoprofen during days 1 and 2 of hospitalization was in the range 6–12 h, which is several times longer than the reported normal value. This finding implied nonlinearity of loxoprofen pharmacokinetics over the current 100-fold dose range, which could affect the accuracy of values simulated by a simplified physiologically based pharmacokinetic (PBPK) model founded on data from a normal dose of 60 mg. The reasons for the delayed eliminations from plasma of loxoprofen and its trans-alcohol metabolite in this case are uncertain, but slight renal impairment (low eGFR values) developed on the second and third hospital days and could be a causal factor.ConclusionsBecause the patient’s level of consciousness had gradually improved, he was discharged on the fourth day of hospitalization. The virtual plasma exposures of loxoprofen and its reduced trans-alcohol metabolite estimated using the current simplified PBPK model were lower than the measured values in the overdose case. The present results based on drug monitoring data and pharmacokinetic predictions could serve as a useful guide in cases of loxoprofen overdose.

【 授权许可】

CC BY