Revealing the early stages of carbamazepine crystallization by cryoTEM and 3D electron diffraction

IUCrJ

article

F. Nudelman¹  S. Parsons¹  H. Xu²  E. T. Broadhurst¹ 

[1] EaStCHEM School of Chemistry and Centre for Science at Extreme Conditions, The University of Edinburgh;Stockholm University

关键词: crystal nucleation;    3D electron diffraction;    polymorphism;    cryoTEM;    carbamazepine.;   

DOI  :  10.1107/S2052252521010101

学科分类：社会科学、人文和艺术（综合）

来源: International Union of Crystallography

【 摘 要 】

Time-resolved carbamazepine crystallization from wet ethanol has been monitored using a combination of cryoTEM and 3D electron diffraction. Carbamazepine is shown to crystallize exclusively as a dihydrate after 180 s. When the timescale was reduced to 30 s, three further polymorphs could be identified. At 20 s, the development of early stage carbamazepine dihydrate was observed through phase separation. This work reveals two possible crystallization pathways present in this active pharmaceutical ingredient.

【 授权许可】

CC BY