Single caudate neurons encode temporally discounted value for formulating motivation for action

eLife

Atsushi Fujimoto¹  Tetsuya Suhara¹  Takafumi Minamimoto¹  Yukiko Hori¹  Yuji Nagai¹  Koki Mimura¹  Erika Kikuchi¹  Kei Oyama¹  Barry J Richmond²  Ken-ichi Inoue³  Masahiko Takada³ 

[1] Department of Functional Brain Imaging, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan;Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, United States;Systems Neuroscience Section, Primate Research Institute, Kyoto University, Inuyama, Japan;

关键词: temporal discounting;    delay;    reward;    motivation;    DREADDs;    monkey;    Rhesus macaque;   

DOI  :  10.7554/eLife.61248

来源: eLife Sciences Publications, Ltd

【 摘 要 】

The term ‘temporal discounting’ describes both choice preferences and motivation for delayed rewards. Here we show that neuronal activity in the dorsal part of the primate caudate head (dCDh) signals the temporally discounted value needed to compute the motivation for delayed rewards. Macaque monkeys performed an instrumental task, in which visual cues indicated the forthcoming size and delay duration before reward. Single dCDh neurons represented the temporally discounted value without reflecting changes in the animal’s physiological state. Bilateral pharmacological or chemogenetic inactivation of dCDh markedly distorted the normal task performance based on the integration of reward size and delay, but did not affect the task performance for different reward sizes without delay. These results suggest that dCDh is involved in encoding the integrated multi-dimensional information critical for motivation.

【 授权许可】

CC BY