Spinal lumbar dI2 interneurons contribute to stability of bipedal stepping

eLife

Baruch Haimson¹  Avihu Klar¹  Aharon Lev-Tov¹  Nimrod Bernat¹  Yoav Hadas¹  Monica A Daley²  Artur Kania³  Yuval Cinnamon⁴ 

[1] Department of Medical Neurobiology, IMRIC, Hebrew University – Hadassah Medical School, Jerusalem, Israel;Ecology and Evolutionary Biology, University of California, Irvine, Irvine, United States;Institut de recherches cliniques de Montréal (IRCM), Montréal, Canada;Institute of Animal Science Poultry and Aquaculture Sci. Dept. Agricultural Research Organization, The Volcani Center, Rishon LeZion, Israel;

关键词: spinal cord;    interneurons;    locomotion;    cerebellum;    spinocerebellar tract;    neural circuits;    Chicken;   

DOI  :  10.7554/eLife.62001

来源: eLife Sciences Publications, Ltd

【 摘 要 】

Peripheral and intraspinal feedback is required to shape and update the output of spinal networks that execute motor behavior. We report that lumbar dI2 spinal interneurons in chicks receive synaptic input from afferents and premotor neurons. These interneurons innervate contralateral premotor networks in the lumbar and brachial spinal cord, and their ascending projections innervate the cerebellum. These findings suggest that dI2 neurons function as interneurons in local lumbar circuits, are involved in lumbo-brachial coupling, and that part of them deliver peripheral and intraspinal feedback to the cerebellum. Silencing of dI2 neurons leads to destabilized stepping in posthatching day 8 hatchlings, with occasional collapses, variable step profiles, and a wide-base walking gait, suggesting that dI2 neurons may contribute to the stabilization of the bipedal gait.

【 授权许可】

CC BY