The frequency of medical reversals in a cross-sectional analysis of high-impact oncology journals, 2009–2018

BMC Cancer

Tyler Crain¹  Vinay Prasad²  Alyson Haslam²  Diana Herrera-Perez³  Emerson Y. Chen³  Myung S. Kim³  Jennifer Gill⁴  Talal Hilal⁵ 

[1] Department of Analytics, Northwest Permanente, Portland, OR, USA;Department of Epidemiology and Biostatistics, University of California, San Francisco, USA;Oregon Health & Science University, Portland, OR, USA;Providence Health & Services, Portland, OR, USA;University of Mississippi Medical Center, Jackson, MS, USA;

关键词: Oncology;    Medical reversal;    Low-value care;   

DOI  :  10.1186/s12885-021-08632-8

来源: Springer

【 摘 要 】

BackgroundIdentifying ineffective practices that have been used in oncology is important in reducing wasted resources and harm. We sought to examine the prevalence of practices that are being used but have been shown in RCTs to be ineffective (medical reversals) in published oncology studies.MethodsWe cross-sectionally analyzed studies published in three high-impact oncology medical journals (2009–2018). We abstracted data relating to the frequency and characterization of medical reversals.ResultsOf the 64 oncology reversals, medications (44%) represented the most common intervention type (39% were targeted). Fourteen (22%) were funded by pharmaceutical/industry only and 56% were funded by an organization other than pharmaceutical/industry. The median number of years that the practice had been in use prior to the reversal study was 9 years (range 1–50 years).ConclusionHere we show that oncology reversals most often involve the administration of medications, have been practiced for years, and are often identified through studies funded by non-industry organizations.

【 授权许可】

CC BY