Comparative epidemiology of gestational diabetes in ethnic Chinese from Shanghai birth cohort and growing up in Singapore towards healthy outcomes cohort

BMC Pregnancy and Childbirth

Qai Ven Yap¹  Kok Hian Tan²  Lynette Pei-Chi Shek³  Shu E Soh³  Fabian Kok Peng Yap⁴  Guoqi Yu⁵  Zhong-Cheng Luo⁶  Jun Zhang⁷  Yuqing Zhang⁸  Hui Xing Lau⁹  Shiao-Yng Chan^1,10  Yap Seng Chong^1,10  Johan Gunnar Eriksson^1,11  Evelyn Xiu Ling Loo^1,12  See Ling Loy^1,13 

[1] Department of Biostatistics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore;Department of Maternal Fetal Medicine, KK Women’s and Children’s Hospital, Singapore, Singapore;Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore;Duke-NUS Medical School, Singapore, Singapore;Department of Paediatrics, KK Women’s and Children’s Hospital, Singapore, Singapore;Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore;Ministry of Education and Shanghai Key Laboratory of Children’s Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;Ministry of Education and Shanghai Key Laboratory of Children’s Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;Department of Obstetrics and Gynecology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, M5G 1X5, Toronto, Canada;Ministry of Education and Shanghai Key Laboratory of Children’s Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;School of Public Health, Guilin Medical College, Guilin, Guangxi, China;Ministry of Education and Shanghai Key Laboratory of Children’s Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;School of Public Health, Shanghai Jiao Tong University, Shanghai, China;Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A*STAR), 30 Medical Drive, 117609, Singapore, Singapore;Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A*STAR), 30 Medical Drive, 117609, Singapore, Singapore;Department of Obstetrics & Gynaecology and Human Potential Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore;Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A*STAR), 30 Medical Drive, 117609, Singapore, Singapore;Department of Obstetrics & Gynaecology and Human Potential Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore;Folkhälsan Research Center, Helsinki, Finland;Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland;Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A*STAR), 30 Medical Drive, 117609, Singapore, Singapore;Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore;Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A*STAR), 30 Medical Drive, 117609, Singapore, Singapore;Department of Reproductive Medicine, KK Women’s and Children’s Hospital, Singapore, Singapore;Duke-NUS Medical School, Singapore, Singapore;

关键词: Asian;    Gestational diabetes mellitus;    International Association of Diabetes and Pregnancy Study Groups;    World Health Organisation;    GUSTO;    Shanghai birth cohort;   

DOI  :  10.1186/s12884-021-04036-5

来源: Springer

【 摘 要 】

BackgroundGestational diabetes mellitus (GDM) has been associated with adverse health outcomes for mothers and offspring. Prevalence of GDM differs by country/region due to ethnicity, lifestyle and diagnostic criteria. We compared GDM rates and risk factors in two Asian cohorts using the 1999 WHO and the International Association of Diabetes and Pregnancy Study Groups (IADPSG) criteria.MethodsThe Shanghai Birth Cohort (SBC) and the Growing Up in Singapore Towards healthy Outcomes (GUSTO) cohort are prospective birth cohorts. Information on sociodemographic characteristics and medical history were collected from interviewer-administered questionnaires. Participants underwent a 2-h 75-g oral glucose tolerance test at 24–28 weeks gestation. Logistic regressions were performed.ResultsUsing the 1999 WHO criteria, the prevalence of GDM was higher in GUSTO (20.8%) compared to SBC (16.6%) (p = 0.046). Family history of hypertension and alcohol consumption were associated with higher odds of GDM in SBC than in GUSTO cohort while obesity was associated with higher odds of GDM in GUSTO. Using the IADPSG criteria, the prevalence of GDM was 14.3% in SBC versus 12.0% in GUSTO. A history of GDM was associated with higher odds of GDM in GUSTO than in SBC, while being overweight, alcohol consumption and family history of diabetes were associated with higher odds of GDM in SBC.ConclusionsWe observed several differential risk factors of GDM among ethnic Chinese women living in Shanghai and Singapore. These findings might be due to heterogeneity of GDM reflected in diagnostic criteria as well as in unmeasured genetic, lifestyle and environmental factors.

【 授权许可】

CC BY