Cervical cancer screening using HPV tests on self-samples: attitudes and preferences of women participating in the VALHUDES study

Archives of Public Health

Severien Van Keer¹  Alex Vorsters¹  Jean Doyen²  Philippe De Sutter³  Gilbert Donders⁴  Steven Weyers⁵  Davy Vanden Broeck⁶  Wiebren A. A. Tjalma⁷  Hélène De Pauw⁸  Marc Arbyn⁹  Eliana Peeters^1,10 

[1] Centre for the Evaluation of Vaccination (CEV), Vaccine & Infectious Disease Institute (VAXINFECTIO), Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk, Antwerp, Belgium;Department Gynaecology-Obstetrics, Liège University Hospital (CHU Liège), Liège, Belgium;Department of Gynaecology & Oncology, Universitair Ziekenhuis Brussel (UZ Brussel) - Vrije Universiteit Brussel (VUB), Brussels, Belgium;Department of Obstetrics and Gynaecology of the General Regional Hospital Heilig Hart (RZ Tienen), Tienen, Belgium;Femicare vzw, Clinical Research for Women, Tienen, Belgium;Department of Obstetrics and Gynaecology, Antwerp University Hospital (UZA), Antwerp, Belgium;Department of Obstetrics and Gynaecology, Ghent University Hospital (UZ Ghent), Ghent, Belgium;Department of Human Structure and Repair, Faculty of Medicine and Health Sciences, University of Ghent, Ghent, Belgium;Laboratory of Molecular Pathology, AML Sonic Healthcare, Antwerp, Belgium;National Reference Centre for HPV, Brussels, Belgium;AMBIOR, Laboratory for Cell Biology & Histology, University of Antwerp, Antwerp, Belgium;International Centre for Reproductive Health, Ghent University, Ghent, Belgium;Multidisciplinary Breast Clinic, Unit Gynaecologic Oncology, Department of Obstetrics and Gynaecology, Antwerp University Hospital (UZA), Edegem, Belgium;Molecular Imaging, Pathology, Radiotherapy, Oncology (MIPRO), Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium;Unit of Cancer Epidemiology, Belgian Cancer Centre, Sciensano, J. Wytsmanstreet 14, B1050, Brussels, Belgium;Unit of Cancer Epidemiology, Belgian Cancer Centre, Sciensano, J. Wytsmanstreet 14, B1050, Brussels, Belgium;Department of Human Structure and Repair, Faculty of Medicine and Health Sciences, University of Ghent, Ghent, Belgium;Unit of Cancer Epidemiology, Belgian Cancer Centre, Sciensano, J. Wytsmanstreet 14, B1050, Brussels, Belgium;Unit of Cancer Epidemiology, Belgian Cancer Centre, Scientific Institute of Public Health, Brussels, Belgium;

关键词: Cervical cancer;    Screening;    Attitudes;    Preferences;    Human papillomavirus;    HPV;    Self-sampling;    Urine;    VALHUDES;   

DOI  :  10.1186/s13690-021-00667-4

来源: Springer

【 摘 要 】

BackgroundInterventions to reach women who do not participate regularly in screening may reduce the risk of cervical cancer. Self-collection of a vaginal specimen has been shown to increase participation. The relative clinical accuracy of human papillomavirus (HPV) testing on first-void urine (with Colli-Pee) and on vaginal self-samples versus on cervical clinician-collected samples is being investigated in the VALHUDES trial. The current study assesses attitudes and experiences regarding self-sampling among women enrolled in VALHUDES.MethodsQuestionnaires from 515 women (age 25–64 years [N = 498]; < 25 [N = 10], age ≥ 65 [N = 3], enrolled between December 2017 - January 2020) referred to colposcopy because of previous cervical abnormalities and enrolled in VALHUDES (NCT03064087) were analysed.ResultsOf the 515 participants, nearly all women confirmed that self-sampling may help in reaching under-screened women (93%). Nevertheless, 44% of the participants stated before starting collection that a clinician-collected sample is more effective than a self-collected sample. After self-sampling, the large majority of women (> 95%) declared that instructions for self-collection were clear, that collection was easy, and that they were confident about having performed the procedure correctly, for both urine and vaginal collection. However, a proportion of women found self-sampling unpleasant (9.5% [49/515] for urine collection; 18.6% [96/515] and 15.5% [80/515] for vaginal sampling with cotton swabs or plastic brushes, respectively). For their next screening round, 57% would prefer self-sampling whereas 41% opted for collection by a clinician. Among women preferring self-sampling, 53% would choose for urine collection, 38% for vaginal self-collection and 9% had no preference. Age did not modify preferences.ConclusionWe conclude that both urine and vaginal self-sampling are well accepted by women, with a preference for urine sampling. Although the large majority of women are confident in their ability to perform self-sampling, four to five over ten women preferred specimen collection by a clinician.Trial registrationThe study VALHUDES was registered in ClinicalTrials.gov (identifier: NCT03064087).

【 授权许可】

CC BY