Optimization of cerebral organoids: a more qualified model for Alzheimer’s disease research

Translational Neurodegeneration

Xiao-Yu Cheng¹  Juan Li²  Hui Yang³  Yin Wang⁴  Yao Yao⁴  Feng-Chen Bi⁵  Wen-Bin Deng⁶  Xiao-Li Guo⁷  Xin-He Yang⁷ 

[1] Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital, Soochow University, 215004, Suzhou, China;Key Laboratory of Traditional Chinese Medicine Modernization, Ministry of Education, Ningxia Medical University, 750004, Yinchuan, China;School of Pharmacy, Ningxia Medical University, 750004, Yinchuan, China;Research Center of Medical Science and Technology, Ningxia Medical University, 750004, Yinchuan, China;School of Basic Medical Sciences, Ningxia Medical University, 750004, Yinchuan, China;School of Basic Medical Sciences, Ningxia Medical University, 750004, Yinchuan, China;Key Laboratory of Traditional Chinese Medicine Modernization, Ministry of Education, Ningxia Medical University, 750004, Yinchuan, China;School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, 510275, Guangzhou, China;School of Pharmacy, Ningxia Medical University, 750004, Yinchuan, China;

关键词: Cerebral organoids;    Alzheimer’s disease;    Pluripotent stem cells;   

DOI  :  10.1186/s40035-021-00252-3

来源: Springer

【 摘 要 】

Alzheimer’s disease (AD) is a neurodegenerative disease that currently cannot be cured by any drug or intervention, due to its complicated pathogenesis. Current animal and cellular models of AD are unable to meet research needs for AD. However, recent three-dimensional (3D) cerebral organoid models derived from human stem cells have provided a new tool to study molecular mechanisms and pharmaceutical developments of AD. In this review, we discuss the advantages and key limitations of the AD cerebral organoid system in comparison to the commonly used AD models, and propose possible solutions, in order to improve their application in AD research. Ethical concerns associated with human cerebral organoids are also discussed. We also summarize future directions of studies that will improve the cerebral organoid system to better model the pathological events observed in AD brains.

【 授权许可】

CC BY