A systematic review of effectiveness of BNT162b2 mRNA and ChAdOx1 adenoviral vector COVID-19 vaccines in the general population

Bulletin of the National Research Centre

Uchenna I. H. Eze¹  Emmanuel A. Adida²  Chinonyerem O. Iheanacho² 

[1] Department of Clinical Pharmacy and Biopharmarcy, Faculty of Pharmacy, Olabisi Onabanjo University, Sagamu, Nigeria;Department of Clinical Pharmacy and Public Health, Faculty of Pharmacy, University of Calabar, PMB 1115, Calabar, Nigeria;

关键词: COVID-19;    SARS-CoV-2;    ChAdOx1 vaccine;    BNT162b2 mRNA vaccine;    Effectiveness;    Adenovirus vector-based vaccine;   

DOI  :  10.1186/s42269-021-00607-w

来源: Springer

【 摘 要 】

BackgroundHigh effectiveness of COVID-19 vaccines is essential for the pandemic control. This study systematically reviewed available evidence on effectiveness of ChAdOx1 and BNT162b2 vaccines in the general population, for improved vaccine policies and strategies.Main body of the abstractUsing several keywords, a search of Scopus, PubMed, Google scholar and Hinari databases was conducted from December 1, 2020 to June 9, 2021. Eligible studies comprising original studies reporting effectiveness of the vaccines, were included following PRISMA guidelines. Individual studies were assessed for quality using National Heart, Lung and Blood Institute quality assessment tool. A total of 1766 titles were retrieved and 11 were included, out of which only 5 were peer-reviewed. Although data availability was limited, studies suggest equivalent effectiveness of BNT162b2 and ChAdOx1 COVID-19 vaccine against SARS-CoV-2 infection and COVID-19 related morbidity and mortality. Vaccine effectiveness increased steadily to about 35 days, with an enhanced effectiveness following the second dose.Short conclusionBNT162 and ChAdOx1 vaccines were associated with equivalent and high effectiveness which increased with time and a second dose in the general population. This encourages continued practice of other preventive measures, particularly during the first week of vaccination, and reinforces the need for a second dose.

【 授权许可】

CC BY