Transfluthrin eave-positioned targeted insecticide (EPTI) reduces human landing rate (HLR) of pyrethroid resistant and susceptible malaria vectors in a semi-field simulated peridomestic space

Malaria Journal

Ummi A. Kibondo¹  Mgeni M. Tambwe²  Lorenz Hofer²  Sarah Moore²  Adam Saddler³ 

[1] Vector Control Product Testing Unit (VCPTU), Environmental Health and Ecological Sciences, Ifakara Health Institute, P.O. Box 74, Bagamoyo, Tanzania;Vector Control Product Testing Unit (VCPTU), Environmental Health and Ecological Sciences, Ifakara Health Institute, P.O. Box 74, Bagamoyo, Tanzania;Health Interventions Unit, Department of Epidemiology & Public Health, Swiss Tropical & Public Health Institute, Socinstrasse 57, 4051, Basel, Switzerland;University of Basel, Petersplatz 1, 4001, Basel, Switzerland;Vector Control Product Testing Unit (VCPTU), Environmental Health and Ecological Sciences, Ifakara Health Institute, P.O. Box 74, Bagamoyo, Tanzania;Health Interventions Unit, Department of Epidemiology & Public Health, Swiss Tropical & Public Health Institute, Socinstrasse 57, 4051, Basel, Switzerland;University of Basel, Petersplatz 1, 4001, Basel, Switzerland;Telethon Kids Institute, Perth, Australia;

关键词: Volatile pyrethroid;    Transfluthrin;    Pyrethroid resistance;    Eave-positioned targeted insecticide;    EPTI;    Anopheles gambiae;    Anopheles arabiensis;    Semi-field system;   

DOI  :  10.1186/s12936-021-03880-2

来源: Springer

【 摘 要 】

BackgroundVolatile pyrethroids (VPs) are proven to reduce human–vector contact for mosquito vectors. With increasing resistance to pyrethroids in mosquitoes, the efficacy of VPs, such as transfluthrin, may be compromised. Therefore, experiments were conducted to determine if the efficacy of transfluthrin eave-positioned targeted insecticide (EPTI) depends on the resistance status of malaria vectors.MethodsRibbons treated with 5.25 g transfluthrin or untreated controls were used around the eaves of an experimental hut as EPTI inside a semi-field system. Mosquito strains with different levels of pyrethroid resistance were released simultaneously, recaptured by means of human landing catches (HLCs) and monitored for 24-h mortality. Technical-grade (TG) transfluthrin was used, followed by emulsifiable concentrate (EC) transfluthrin and additional mosquito strains. Generalized linear mixed models with binomial distribution were used to determine the impact of transfluthrin and mosquito strain on mosquito landing rates and 24-h mortality.ResultsEPTI treated with 5.25 g of either TG or EC transfluthrin significantly reduced HLR of all susceptible and resistant Anopheles mosquitoes (Odds Ratio (OR) ranging from 0.14 (95% Confidence Interval (CI) [0.11–0.17], P < 0.001) to 0.57, (CI [0.42–0.78] P < 0.001). Both TG and EC EPTI had less impact on landing for the resistant Anopheles arabiensis (Mbita strain) compared to the susceptible Anopheles gambiae (Ifakara strain) (OR 1.50 [95% CI 1.18–1.91] P < 0.001) and (OR 1.67 [95% CI 1.29–2.17] P < 0.001), respectively. The EC EPTI also had less impact on the resistant An. arabiensis (Kingani strain) (OR 2.29 [95% CI 1.78–2.94] P < 0.001) compared to the control however the TG EPTI was equally effective against the resistant Kingani strain and susceptible Ifakara strain (OR 1.03 [95% CI 0.82–1.32] P = 0.75). Finally the EC EPTI was equally effective against the susceptible An. gambiae (Kisumu strain) and the resistant An. gambiae (Kisumu-kdr strain) (OR 0.98 [95% CI 0.74–1.30] P = 0.90).ConclusionsTransfluthrin-treated EPTI could be useful in areas with pyrethroid-resistant mosquitoes, but it remains unclear whether stronger resistance to pyrethroids will undermine the efficacy of transfluthrin. At this dosage, transfluthrin EPTI cannot be used to kill exposed mosquitoes.

【 授权许可】

CC BY