Association between hypertension and coffee drinking based on CYP1A2 rs762551 single nucleotide polymorphism in Taiwanese

Nutrition & Metabolism

Disline Manli Tantoh¹  Yung-Po Liaw¹  Chien-Chou Hou²  Chuan-Chao Lin³  Pei-Hsin Chen⁴  Hao-Jan Yang⁵ 

[1] Department of Medical Imaging, Chung Shan Medical University Hospital, Taichung City, Taiwan;Department of Public Health and Institute of Public Health, Chung Shan Medical University, No. 110 Sec. 1 Jianguo N. Road, 40201, Taichung City, Taiwan;Department of Medical Sociology and Social Work, Chung Shan Medical University, Taichung City, Taiwan;Department of Social Service, Chung Shan Medical University Hospital, Taichung City, Taiwan;Department of Physical Medicine and Rehabilitation, Chung Shan Medical University Hospital, Taichung City, Taiwan;School of Medicine, Chung Shan Medical University, Taichung City, Taiwan;Department of Public Health and Institute of Public Health, Chung Shan Medical University, No. 110 Sec. 1 Jianguo N. Road, 40201, Taichung City, Taiwan;Department of Public Health and Institute of Public Health, Chung Shan Medical University, No. 110 Sec. 1 Jianguo N. Road, 40201, Taichung City, Taiwan;Department of Family and Community Medicine, Chung Shan Medical University Hospital, Taichung City, Taiwan;

关键词: Hypertension;    Coffee drinking;    CYP1A2;    rs762551;    Taiwanese;   

DOI  :  10.1186/s12986-021-00605-9

来源: Springer

【 摘 要 】

BackgroundHypertension increases the likelihood of cardiovascular diseases (CVDs). Cytochrome P450 1A2 (CYP1A2) single nucleotide polymorphism (SNP) is related to caffeine metabolism and the risk of CVD among coffee drinkers. CYP1A2 rs762551 influenced the risk of stroke among hypertensive patients. We examined the relationship between hypertension and coffee drinking based on CYP1A2 rs762551 SNP in Taiwanese adults.MethodsWe used data contained in the Taiwan Biobank database (2011–2018) and included 19,133 participants having complete information on hypertension, rs762551 polymorphism, coffee intake, etc. The risk of hypertension was determined using multiple logistic regression.ResultsCoffee intake was significantly associated with a lower risk of hypertension. The odds ratio (OR), 95% confidence interval (CI), and p-value were 0.877, 0.807–0.954, and 0.0032, respectively. CYP1A2 rs762551 was not significantly associated with the risk of hypertension, but it had a significant interactive association with coffee drinking (p value = 0.0303). After stratification by rs762551 genotypes, the inverse coffee drinking-hypertension association was retained, but significant results were observed only in those with the AC + CC genotype (OR 0.678, 95% CI 0.722–900, p value = 0.0001). According to the combination of coffee drinking and rs762551 genotypes (reference group: no coffee drinking and rs762551 AA), the coffee drinking-AC + CC group had a lower risk of hypertension (OR 0.888, 95% CI 0.789–0.999, p value = 0.0483).ConclusionCoffee drinking, particularly among individuals with the CYP1A2 rs762551 AC + CC genotype was associated with lower odds of hypertension.

【 授权许可】

CC BY