Transcranial color-coded duplex sonography assessment of cerebrovascular reactivity to carbon dioxide: an interventional study

BMC Neurology

Giovanna Brandi¹  Stephanie Klinzing¹  Markus Bèchir¹  Alberto Pagnamenta²  Federica Stretti³ 

[1] Institute for Intensive Medicine, University Hospital of Zurich, Raemistrasse 100, CH-8091, Zurich, Switzerland;Intensive Care Unit, Regional Hospital of Mendrisio, Mendrisio, Switzerland;Unit of Clinical Epidemiology, Ente Ospedaliero Cantonale, Bellinzona, Switzerland;Division of Pneumology, University of Geneva, Geneva, Switzerland;Intensive Care Unit, Westmead Hospital, Westmead, NSW, Australia;

关键词: Transcranial color-coded duplex sonography;    Intensive care ultrasound;    CO2 reactivity;    Traumatic brain injury;    Cerebral blood flow measurements;   

DOI  :  10.1186/s12883-021-02310-9

来源: Springer

【 摘 要 】

BackgroundThe investigation of CO2 reactivity (CO2-CVR) is used in the setting of, e.g., traumatic brain injury (TBI). Transcranial color-coded duplex sonography (TCCD) is a promising bedside tool for monitoring cerebral hemodynamics. This study used TCCD to investigate CO2-CVR in volunteers, in sedated and mechanically ventilated patients without TBI and in sedated and mechanically ventilated patients in the acute phase after TBI.MethodsThis interventional investigation was performed between March 2013 and February 2016 at the surgical ICU of the University Hospital of Zurich. Ten volunteers (group 1), ten sedated and mechanically ventilated patients (group 2), and ten patients in the acute phase (12–36 h) after severe TBI (group 3) were included. CO2-CVR to moderate hyperventilation (∆ CO2 -5.5 mmHg) was assessed by TCCD.ResultsCO2-CVR was 2.14 (1.20–2.70) %/mmHg in group 1, 2.03 (0.15–3.98) %/mmHg in group 2, and 3.32 (1.18–4.48)%/mmHg in group 3, without significant differences among groups.ConclusionOur data did not yield evidence for altered CO2-CVR in the early phase after TBI examined by TCCD.Trial registrationPart of this trial was performed as preparation for the interventional trial in TBI patients (clinicaltrials.gov NCT03822026, 30.01.2019, retrospectively registered).

【 授权许可】

CC BY