Critical role of triglycerides for adiponectin levels in hepatitis C: a joint study of human and HCV core transgenic mice

BMC Immunology

Chun-Ming Fan¹  Ming-Shyan Lin²  Jing-Hong Hu³  Shiang-Chi Chen⁴  Ming-Ling Chang⁵  Chia-Jung Kuo⁵  Rong-Nan Chien⁶  Ming-Yu Chang⁷  Li-Heng Pao⁸ 

[1] Department of Biomedical Sciences, Chang Gung University, Taoyuan, Taiwan;Department of Cardiology, Heart Failure Center, Chang Gung Memorial Hospital, Yunlin, Taiwan;Department of Internal Medicine, Chang Gung Memorial Hospital, Yunlin, Taiwan;Department of Nursing, Taipei Medical University, Taipei, Taiwan;Division of Hepatology, Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, No 5, Fu Hsing Street, Kuei Shan, Taoyuan, Taiwan;Department of Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan;Division of Hepatology, Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, No 5, Fu Hsing Street, Kuei Shan, Taoyuan, Taiwan;Department of Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan;Liver Research Unit, Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, No 5, Fu Hsing Street, Kuei Shan, Taoyuan, Taiwan;Division of Pediatric Neurologic Medicine, Chang Gung Children’s Hospital, Taoyuan, Taiwan;Division of Pediatrics, Chang Gung Memorial Hospital, Keelung, Taiwan;Graduate Institute of Health-Industry Technology, Chang Gung University of Science and Technology, Taoyuan, Taiwan;Research Center for Industry of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, Taiwan;

关键词: HCV;    Adiponectin;    Triglycerides;    HOMA-IR;    SVR;    DAA;    HCV core;   

DOI  :  10.1186/s12865-021-00445-5

来源: Springer

【 摘 要 】

BackgroundBoth hepatitis C virus (HCV) infection and adiponectin are critically involved in metabolism. The reversal and associations of altering adiponectin levels after sustained virological responses (SVRs) following direct-acting antivirals (DAA) in HCV-infected patients remained elusive.MethodsA joint study was conducted in a prospective cohort of 427 HCV-infected patients and a line of HCV core transgenic mice.ResultsOf 427, 358 had completed a course of DAA therapy and 353 had SVRs. At baseline, male sex (95% CI β: − 1.44 to − 0.417), estimated glomerular filtration rate (eGFR) (− 0.025 to − 0.008), triglycerides (− 0.015 to − 0.005), and fibrosis-4 levels (0.08–0.297) were associated with adiponectin levels; BMI (0.029–0.327) and triglycerides levels (0.01–0.03) were associated with homeostatic model assessment for insulin resistance (HOMA-IR) in HCV-infected patients. At 24-week post-therapy, in SVR patients, male sex (− 1.89 to − 0.5) and eGFR (− 0.02 to − 0.001) levels were associated with adiponectin levels, levels of BMI (0.094–0.335) and alanine transaminase (0.018–0.078) were associated with HOMA-IR; compared with baseline levels, adiponectin levels decreased (6.53 ± 2.77 vs. 5.45 ± 2.56 μg/mL, p < 0.001). In 12-month-old HCV core transgenic mice with hepatic steatosis, triglyceride levels (0.021–0.111) were associated with adiponectin levels, and hepatic adipopnectin expression was comparable with that of control mice.ConclusionsTriglycerides and hepatic fibrosis are associated with HCV-specific alteration of adiponectin levels, and adiponectin may affect insulin sensitivity through triglycerides during HCV infection. In DAA-treated patients, after SVR, adiponectin levels decreased and the linking function of triglycerides between adiponectin and insulin sensitivity vanished. Moreover, HCV core with hepatic steatosis might affect extrahepatic adiponectin expression through triglycerides.

【 授权许可】

CC BY