Innovative method of alopecia treatment by autologous adipose-derived SVF

Stem Cell Research & Therapy

Byung-Rok Do¹  Ji Hyang Kim¹  Young Hoo Do²  Jun Woo Choi³  Young Jun Lee³  Sun Jong Kim³  Joo Chan Lee³  Myung Jin Kim³  Sung Ill Chung⁴  Do Ha Kim⁴ 

[1] Biotechnology Research Institute, Hurim BioCell Inc., Seoul, Korea;Department of Applied Statistics, College of Natural Science, Hanyang University, Seoul, Korea;Department of Bioconvergence, HurimBioCell Inc., Seoul, Korea;Top Plastic Surgery, Teheran-ro 111, Gangnam-gu, Seoul, Korea;

关键词: Stromal vascular fraction (SVF);    Alopecia;    Hair loss;    Baldness;   

DOI  :  10.1186/s13287-021-02557-6

来源: Springer

【 摘 要 】

BackgroundAlopecia refers to a condition developed by gradual reduction of hair loss by various abnormal causes such as endocrine system, genetic factors, and stress. Stromal vascular fraction (SVF) isolated from the fat is one of the latest innovative solutions in the field of regeneration therapy. We focused on presenting effectiveness of clinical cases to improve AGA through transplantation of autologous SVF into the scalp.ObjectiveTo confirm the efficacy of the autologous SVF usage to the patients with AGA.MethodsNine patients (age range 43–64 years; 4 men, grade IV to V and 5 women, grade I to III), who are suffering from androgenic alopecia (AGA), were treated with single transplantation of autologous SVF in the upper scalp. Autologous SVF was isolated and characterized prior to the injection of live 7–9 × 106 cells into the patients’ treatment site. The hair loss improvement effect was assessed by three test criteria: hair skin quality, hair thickness and hair density 3 and 6 months after post-injection compared to pre-injection status.ResultsHair density of SVF-treated side was significantly increased after 3 and 6 months of transplantation compared to non-treated side (P = 0.01 and P = 0.009 per each). And significant improvement in the score of the keratin on the scalp was seen in the injected area as compared to the non-injected area 6 months after transplantation (P = 0.032). Although thickness increase was observed at 3 and 6 months after transplantation, there was no statistical significance (P = 0.142 and 0.155, respectively).ConclusionsOne transplantation of autologous SVF for the AGA patients, hair density and score for the keratin were significantly increased within 6 months. This study shows that SVF is a very effective way to treat hair loss and most of subjects are satisfied with the result after treatment.

【 授权许可】

CC BY