Dynamic changes in liver function parameters in patients with coronavirus disease 2019: a multicentre, retrospective study

BMC Infectious Diseases

Guo-Tao Li¹  Guang-Lin Cui¹  Qing-Lei Zeng²  Zu-Jiang Yu²  Fanpu Ji³  Guang-Ming Li⁴  Guo-Qiang Zhang⁵  Jiang-Hai Xu⁶  Guo-Fan Zhang⁷  Wan-Bao Lin⁸  Fu-Sheng Wang⁹ 

[1] Department of Clinical Laboratory, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China;Department of Infectious Diseases and Hepatology, The First Affiliated Hospital of Zhengzhou University, No. 1 Eastern Jianshe Road, 450052, Zhengzhou, Henan, China;Department of Infectious Diseases, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China;Key Laboratory of Environment and Genes Related To Diseases, Ministry of Education of China, Xi’an Jiaotong University, Xi’an, Shaanxi, China;Department of Infectious Diseases, The Sixth People’s Hospital of Zhengzhou City, Zhengzhou, Henan, China;The Department of Infectious Diseases, Luoyang Central Hospital, Luoyang, Henan, China;The Department of Infectious Diseases, The Fifth People’s Hospital of Anyang City, Anyang, Henan, China;The Department of Infectious Diseases, The First Affiliated Hospital of Nanyang Medical College, Nanyang, Henan, China;The Department of Infectious Diseases, Xinyang Central Hospital, Xinyang, Henan, China;Treatment and Research Center for Infectious Diseases, The Fifth Medical Center of Chinese PLA General Hospital, National Clinical Research Centre for Infectious Diseases, No. 100 Western 4th Middle Ring Road, Fengtai District, Beijing, China;

关键词: Aalanine aminotransferase;    Aspartate aminotransferase;    Coronavirus disease 2019;    Dynamic changes;    Liver function;    Liver injury;    Severe acute respiratory syndrome coronavirus 2;   

DOI  :  10.1186/s12879-021-06572-z

来源: Springer

【 摘 要 】

BackgroundLiver injuries have been reported in patients with coronavirus disease 2019 (COVID-19). This study aimed to investigate the clinical role played by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).MethodsIn this multicentre, retrospective study, the parameters of liver function tests in COVID-19 inpatients were compared between various time-points in reference to SARS-CoV-2 shedding, and 3 to 7 days before the first detection of viral shedding was regarded as the reference baseline.ResultsIn total, 70 COVID-19 inpatients were enrolled. Twenty-two (31.4%) patients had a self-medication history after illness. At baseline, 10 (14.3%), 7 (10%), 9 (12.9%), 2 (2.9%), 15 (21.4%), and 4 (5.7%) patients already had abnormal alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyl transferase (GGT), alkaline phosphatase (ALP), albumin, and total bilirubin (TBIL) values, respectively. ALT and AST abnormal rates and levels did not show any significant dynamic changes during the full period of viral shedding (all p > 0.05). The GGT abnormal rate (p = 0.008) and level (p = 0.033) significantly increased on day 10 of viral shedding. Meanwhile, no simultaneous significant increases in abnormal ALP rates and levels were observed. TBIL abnormal rates and levels significantly increased on days 1 and 5 of viral shedding (all p < 0.05). Albumin abnormal decrease rates increased, and levels decreased consistently from baseline to SARS-CoV-2 clearance day (all p < 0.05). Thirteen (18.6%) patients had chronic liver disease, two of whom died. The ALT and AST abnormal rates and levels did not increase in patients with chronic liver disease during SARS-CoV-2 shedding.ConclusionsSARS-CoV-2 does not directly lead to elevations in ALT and AST but may result in elevations in GGT and TBIL; albumin decreased extraordinarily even when SARS-CoV-2 shedding ended.

【 授权许可】

CC BY