Analysis of annexin-A1 in the macrophages and apoptotic cells of patients with cutaneous leishmaniasis

Sociedade Brasileira de Medicina Tropical. Revista

article

Mariana Nascimento Pona¹  Jordhana Mendonça Dietrich²  Joselina Maria da Silva³  Helen Aguiar Lemes da Silva²  Marcia Hueb⁴  Amilcar Sabino Damazo³ 

[1] Universidade Federal de Mato Grosso;Universidade Federal de Mato Grosso, Programa de Pós-Graduação em Ciências da Saúde;Universidade Federal de Mato Grosso, Programa de Pós-Graduação em Ciências da Saúde, Brasil. Universidade Federal de Mato Grosso, Departamento de Ciências Básicas em Saúde;Universidade Federal de Mato Grosso, Departamento de Clínica Médica

关键词: Cutaneous leishmaniasis;    Skin;    Macrophage;    Apoptosis;    Annexin-A1;   

DOI  :  10.1590/0037-8682-0756-2020

学科分类：农业科学（综合）

来源: Sociedade Brasileira de Medicina Tropical

【 摘 要 】

Introduction: This study aimed to determine the number of macrophages and apoptotic cells and perform annexin-A1 detection in patients with leishmaniasis. Methods: Patients with Leishmania infection were admitted to Júlio Müller University Hospital. Results: The number of apoptotic cells was higher in the exudative granulomatous reaction. The exudative cellular reaction displayed higher levels of annexin-A1 detection in macrophages and apoptotic cells. The correlation between annexin-A1 detection in apoptotic cells and macrophages was observed in exudative necrotic reaction and exudative necrotic-granulomatous reaction. Conclusions: Our data demonstrate the relevance of annexin-A1 in the regulation of apoptosis and phagocytosis in leishmaniasis.

【 授权许可】

CC BY