Mechanism of action of glycyrrhizin against Plasmodium falciparum

Memorias do Instituto Oswaldo Cruz

article

Maria de Nazaré Correia Soeiro¹  Gérard Vergoten²  Christian Bailly³ 

[1] Instituto Oswaldo Cruz, Laboratório de Biologia Celular;University of Lille, Institut de Chimie Pharmaceutique Albert Lespagnol;OncoWitan

关键词: cholesterol;    glycyrrhizin;    glyoxalase 1;    HMGB1;    Malaria;    Plasmodium;   

DOI  :  10.1590/0074-02760210084

学科分类：地质学

来源: Bioline International

【 摘 要 】

Extracts of the plant Glycyrrhiza glabra (licorice) are used in traditional medicine to treat malaria. The main active components are the saponin glycyrrhizin (GLR) and its active metabolite glycyrrhetinic acid (GA) which both display activities against Plasmodium falciparum. We have identified three main mechanisms at the origin of their anti-plasmodial activity: (i) drug-induced disorganisation of membrane lipid rafts, (ii) blockade of the alarmin protein HMGB1 and (iii) potential inhibition of the detoxifying enzyme glyoxalase 1 (GLO-1) considered as an important drug target for malaria. Our analysis shed light on the mechanism of action of GLR against P. falciparum.

【 授权许可】

Free