Prognostic value of 18F-FDG PET/CT parameters and histopathologic variables in head and neck cancer

Revista Brasileira de Otorrinolaringologia

article

Hale Aslan¹  Gul Cekin²  Ercan Pinar¹  Mustafa Yazir¹  Abdulkadir Imre¹  Murat Songu¹  Akif Islek³  Ibrahim Aladag¹  Ismail Semih Oncel¹ 

[1]Katip Celebi University School of Medicine, Department of Otolaryngology Head and Neck Surgery

[2]Katip Celebi University School of Medicine, Department of Nuclear Medicine

[3]Mardin Nusaybin State Hospital

关键词: Head and neck cancer 18F-FDG PET/CT;    Prognosis;    Metabolic parameters;   

DOI  :  10.1016/j.bjorl.2019.10.014

学科分类：医学（综合）

来源: Associacao Brasileira de Otorrinolaringologia e Cirurgia Cervicofacial

【 摘 要 】

Introduction: 18F-fluorodeoxyglucose positron emission tomography/computed tomography parameters such as; maximum standardized uptake values, standard metabolic tumor volume and otal lesion glycosis are important prognostic biomarkers in cancers. Objective: To investigate the prognostic value of these parameters in patients with head and neck cancers. Methods: We performed a retrospective study including 47 patients with head and neck cancer who underwent18F-fluorodeoxyglucose positron emission tomography/computed tomography prior to treatment. Standard metabolic tumor volume, otal lesion glycosis and standardized uptake were measured for each patient. The prognostic value of quantitative 18F-fluorodeoxyglucose positron emission tomography/computed tomography parameters and clinicopathologic variables on disease free survival and overall survival were analyzed. Results: The median (range) standard metabolic tumor volume and otal lesion glycosis and standardized uptake were 7.63 cm3 (0.6---34.3), 68.9 g (2.58---524.5 g), 13.89 (4.89---33.03 g/mL), respectively. Lymph node metastases and tumour differentiation were significant variables for disease free survival and overall survival, however, all 18F-fluorodeoxyglucose positron emission tomography/computed tomography parameters were not associated with disease- free survival and overall survival. Conclusion: Pretreatment quantities positron emission tomography parameters did not predict survival in head and neck cancer.

【 授权许可】

CC BY