P-I metalloproteinases and L-amino acid oxidases from Bothrops species inhibit angiogenesis

Journal of venomous animals and toxins

article

Shreesha K. Bhat¹  Manjunath B. Joshi¹  Sampara Vasishta¹  Rajesh N. Jagadale²  Setlur G. Biligiri²  Monika A. Coronado³  Raghuvir K. Arni³  Kapaettu Satyamoorthy¹ 

[1] Manipal School of Life Sciences;Juggat Pharma, Jagadale Industries;Multiuser Center for Biomolecular Innovation, Department of Physics, São Paulo State University (UNESP)

关键词: P-I metalloproteinases;    LAAO;    Bothrops;    Anti-angiogenic;    Snake venom;   

DOI  :  10.1590/1678-9199-JVATITD-2020-0180

学科分类：药理学

来源: BioMed Central

【 摘 要 】

Background: Snake venoms are composed of pharmacologically active proteins that are evolutionarily diverse, stable and specific to targets. Hence, venoms have been explored as a source of bioactive molecules in treating numerous diseases. Recent evidences suggest that snake venom proteins may affect the formation of new blood vessels. Excessive angiogenesis has been implicated in several pathologies including tumours, diabetic retinopathy, arthritis, inter alia . In the present study, we have examined the effects of P-I metalloproteinases isolated from Bothrops moojeni (BmMP-1) and Bothrops atrox (BaMP-1) and L-amino acid oxidases (LAAO) isolated from B. moojeni (BmLAAO) and B. atrox (BaLAAO) on biochemical and functional aspects of angiogenesis.

【 授权许可】

CC BY