Novel neuroprotective peptides in the venom of the solitary scoliid wasp Scolia decorata ventralis

Journal of venomous animals and toxins

article

Carlos Alberto-Silva¹  Fernanda Calheta Vieira Portaro²  Roberto Tadashi Kodama²  Halyne Queiroz Pantaleão¹  Marisa Rangel²  Ken-ichi Nihei³  Katsuhiro Konno⁴ 

[1] Natural and Humanities Sciences Center, Experimental Morphophysiology Laboratory, Federal University of ABC (UFABC);Immunochemistry Laboratory, Butantan Institute;Faculty of Agriculture, Utsunomiya University;Institute of Natural Medicine, University of Toyama

关键词: Comprehensive analysis;    LC-ESI-MS;    Solitary wasp;    Venom;    Neuroprotective peptide;   

DOI  :  10.1590/1678-9199-JVATITD-2020-0171

学科分类：药理学

来源: BioMed Central

【 摘 要 】

Background Solitary wasp venoms may be a rich source of neuroactive substances, since their venoms are used for paralyzing preys. We have been exploring bioactive constituents of solitary wasp venoms and, in this study, the component profile of the venom from a solitary scoliid wasp, Scolia decorata ventralis , was investigated through a comprehensive analysis using LC-MS. Two peptides were synthesized, and their neuroprotective properties were evaluated.

【 授权许可】

CC BY