Dehydrobufotenin extracted from the Amazonian toad Rhinella marina (Anura: Bufonidae) as a prototype molecule for the development of antiplasmodial drugs

Journal of venomous animals and toxins

article

Felipe Finger Banfi¹  Gabriela Camila Krombauer¹  Amanda Luisa da Fonseca²  Renata Rachide Nunes²  Silmara Nunes Andrade²  Millena Alves de Rezende²  Mariana Helena Chaves³  Evaldo dos Santos Monção, Filho³  Alex Guterres Taranto²  Domingos de Jesus Rodrigues⁴  Gerardo Magela Vieira, Júnior³  Whocely Victor de Castro⁵  Fernando de Pilla Varotti²  Bruno Antonio Marinho Sanchez¹ 

[1] Laboratory of Immunopathology and Tropical Diseases, Health Education and Research Center (NUPADS), Institute of Health Sciences, Federal University of Mato Grosso;Research Center on Biological Chemistry (NQBio), Federal University of São João Del Rei;Department of Chemistry, Federal University of Piauí;Center for Biodiversity Studies in the Amazon Region of Mato Grosso (NEBAM), Federal University of Mato Grosso;Quality Control Laboratory, Federal University of São João Del Rei

关键词: Bufadienolides;    Antimalarial drug Docking;    Natural compounds;   

DOI  :  10.1590/1678-9199-JVATITD-2020-0073

学科分类：药理学

来源: BioMed Central

【 摘 要 】

Background: The resistance against antimalarial drugs represents a global challenge in the fight and control of malaria. The Brazilian biodiversity can be an important tool for research and development of new medicinal products. In this context, toxinology is a multidisciplinary approach on the development of new drugs, including the isolation, purification, and evaluation of the pharmacological activities of natural toxins. The present study aimed to evaluate the cytotoxicity, as well as the antimalarial activity in silico and in vitro of four compounds isolated from Rhinella marina venom as potential oral drug prototypes.

【 授权许可】

CC BY