A Kunitz-type peptide from Dendroaspis polylepis venom as a simultaneous inhibitor of serine and cysteine proteases

Journal of venomous animals and toxins

article

Roberto Tadashi Kodama¹  Alexandre Kazuo Kuniyoshi¹  Cristiane Castilho Fernandes da Silva¹  Daniela Cajado-Carvalho¹  Bruno Duzzi¹  Douglas Ceolin Mariano²  Daniel C. Pimenta²  Rafael Borges³  Wilmar Dias da Silva¹  Fernanda Calheta Vieira Portaro¹ 

[1] Laboratory of Immunochemistry, Butantan Institute;Laboratory of Biochemistry and Biophysics, Butantan Institute;Department of Physics and Biophysics, Botucatu Biosciences Institute(IBB), São Paulo State University (UNESP)

关键词: Dendroaspis polylepis venom;    Inhibitor;    Serine peptidase;    Cysteine peptidase;    Kunitz-type peptide;   

DOI  :  10.1590/1678-9199-JVATITD-2020-0037

学科分类：药理学

来源: BioMed Central

【 摘 要 】

Background: Proteases play an important role for the proper physiological functions of the most diverse organisms. When unregulated, they are associated with several pathologies. Therefore, proteases have become potential therapeutic targets regarding the search for inhibitors. Snake venoms are complex mixtures of molecules that can feature a variety of functions, including peptidase inhibition. Considering this, the present study reports the purification and characterization of a Kunitz-type peptide present in the Dendroaspis polylepis venom as a simultaneous inhibitor of elastase-1 and cathepsin L.

【 授权许可】

CC BY