Recombinant antibodies against Iranian cobra venom as a new emerging therapy by phage display technology

Journal of venomous animals and toxins

article

Ali Nazari¹  Maedeh Samianifard¹  Hadi Rabie²  Abbas Zare Mirakabadi² 

[1] Department of Biochemistry and Proteomics, Razi Vaccine and Serum Research Institute, Agricultural Research;Department of Venomous Animals, Razi Vaccine and Serum Research Institute, Agricultural Research

关键词: Antibody phage display;    Venom;    Antivenom;    Purification;   

DOI  :  10.1590/1678-9199-JVATITD-2019-0099

学科分类：药理学

来源: BioMed Central

【 摘 要 】

Background: The production of antivenom from immunized animals is an established treatment for snakebites; however, antibody phage display technology may have the capacity to delivery results more quickly and with a better match to local need. Naja oxiana , the Iranian cobra, is a medically important species, responsible for a significant number of deaths annually. This study was designed as proof of principle to determine whether recombinant antibodies with the capacity to neutralize cobra venom could be isolated by phage display.

【 授权许可】

CC BY