Analgesic and side effects of intravenous recombinant Phα1β

Journal of venomous animals and toxins

article

Flavia Karine Rigo¹  Mateus Fortes Rossato²  Vanessa Borges²  Juliana Figueira da Silva³  Elizete Maria Rita Pereira³  Ricardo Andrez Machado de Ávila¹  Gabriela Trevisan¹  Duana Carvalho dos Santos³  Danuza Montijo Diniz³  Marco Aurélio Romano Silva⁴  Célio José de Castro, Junior³  Thiago Mattar Cunha²  Juliano Ferreira⁵  Marcus Vinicius Gomez³ 

[1] Graduate Program in Health Sciences, University of the Extreme South of Santa Catarina (UNESC);Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo (USP);Institute of Education and Research of Santa Casa Belo Horizonte, Santa Casa of Belo Horizonte Group;Department of Neurosciences, School of Medicine, Federal University of Minas Gerais (UFMG);Department of Pharmacology, Federal University of Santa Catarina

关键词: Recombinant Phα1β;    Analgesia;    Neuropathic pain;    Intravenous drug delivery system;    Side effects;    Cardiac function;    Motor activity;    Biochemicals;   

DOI  :  10.1590/1678-9199-JVATITD-2019-0070

学科分类：药理学

来源: BioMed Central

【 摘 要 】

Background: Intrathecal injection of voltage-sensitive calcium channel blocker peptide toxins exerts analgesic effect in several animal models of pain. Upon intrathecal administration, recombinant Phα1β exerts the same analgesic effects as the those of the native toxin. However, from a clinical perspective, the intrathecal administration limits the use of anesthetic drugs in patients. Therefore, this study aimed to investigate the possible antinociceptive effect of intravenous recombinant Phα1β in rat models of neuropathic pain, as well as its side effects on motor, cardiac (heart rate and blood pressure), and biochemical parameters.

【 授权许可】

CC BY