Repair of Occipital Bone Defects in Neurofibromatosis Type 1 by Means of CAD/CAM Prefabricated Titanium Plates

Craniomaxillofacial Trauma & Reconstruction

article

Reinhard E. Friedrich¹  Pedram Emami²  Christian Hagel³  Johannes Wikner¹  Henning Hanken¹ 

[1] Department of Oral and Craniomaxillofacial Surgery, Eppendorf University Hospital;Department of Neurosurgery, Eppendorf University Hospital;Department of Neuropathology, Eppendorf University Hospital

关键词: neurofibromatosis type 1;    lambdoid suture;    calvarial defect;    plexiform neurofibroma;    CAD/CAM reconstruction;   

DOI  :  10.1055/s-0037-1608699

来源: Thieme Medical Publishers, Inc.

【 摘 要 】

Certain skeletal defects may develop in neurofibromatosis type 1 (NF1), a common tumor-suppressor syndrome, such as cranial lesions confined to the lambdoid suture region. Here, we report on the repair of osseous defects of occipital bone in a NF1 patient with history of skull trauma and tumorous hemorrhage. Computer-aided design and computer-aided manufacturing (CAD/CAM)-assisted devices were applied to safely close the bone defects. The variable phenotype of NF1 in the occipital skull region is discussed and a brief review is presented on NF1-related therapies for tumors and malformations of the occipitoparietal skull region.

【 授权许可】

Unknown