A Review of CXCL1 in Cardiac Fibrosis

Frontiers in Cardiovascular Medicine

article

Cheng-Long Wu¹  Ran Yin¹  Su-Nan Wang¹  Ru Ying¹ 

[1] Department of Cardiology, The First Affiliated Hospital of Nanchang University

关键词: chemokine C-X-C motif ligand-1;    cardiac remodeling;    cardiac fibrosis;    inflammation;    atrial fibrillation;   

DOI  :  10.3389/fcvm.2021.674498

学科分类：地球科学(综合)

来源: Frontiers

【 摘 要 】

Chemokine C-X-C motif ligand-1 (CXCL1), principally expressed in neutrophils, macrophages and epithelial cells, is a valid pro-inflammatory factor which performs an important role in mediating the infiltration of neutrophils and monocytes/macrophages. Elevated serum level of CXCL1 is considered a pro-inflammatory reaction by the organism. CXCL1 is also related to diverse organs fibrosis according to relevant studies. A growing body of evidence suggests that CXCL1 promotes the process of cardiac remodeling and fibrosis. Here, we review structure and physiological functions of CXCL1 and recent progress on the effects and mechanisms of CXCL1 in cardiac fibrosis. In addition, we explore the role of CXCL1 in the fibrosis of other organs. Besides, we probe the possibility that CXCL1 can be a therapeutic target for the treatment of cardiac fibrosis in cardiovascular diseases.

【 授权许可】

CC BY