Aortic Valve Sclerosis in High-Risk Coronary Artery Disease Patients

Frontiers in Cardiovascular Medicine

article

Veronika A. Myasoedova¹  Stefano Genovese¹  Laura Cavallotti¹  Alice Bonomi¹  Mattia Chiesa¹  Jeness Campodonico¹  Maurizio Rondinelli¹  Nicola Cosentino¹  Damiano Baldassarre¹  Fabrizio Veglia¹  Mauro Pepi¹  Francesco Alamanni¹  Gualtiero I. Colombo¹  Giancarlo Marenzi¹  Paolo Poggio¹ 

[1] Centro Cardiologico Monzino Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS)

关键词: aortic valve sclerosis;    high-risk coronary artery disease;    acute myocardial infarction;    all-cause mortality;    coronary artery bypass graft;   

DOI  :  10.3389/fcvm.2021.711899

学科分类：地球科学(综合)

来源: Frontiers

【 摘 要 】

Background: Current knowledge regarding the relationship between aortic valve sclerosis (AVSc), cardiovascular risk factors, and mortality in patients with known coronary artery disease (CAD) is still unclear. The present study aimed at investigating the prevalence of AVSc as well as its association with long-term all-cause mortality in high-risk CAD patients that has never been explored in large cohorts thus far. Methods and Results: In this retrospective and observational cohort study we enrolled high-risk CAD patients, hospitalized at Centro Cardiologico Monzino (CCM), Milan, Italy, between January 2006 and December 2016. The morphology and function of the aortic valve were assessed from the recorded echocardiographic images to evaluate the presence of AVSc, defined as a non-uniform thickening of the aortic leaflets with no consequences on hemodynamics. Data on 5-year all-cause mortality was retrieved from a Regional database. Of the 5,489 patients initially screened, 4,938 (mean age 67 ± 11 years, 3,954 [80%] men) were enrolled in the study. In the overall population, AVSc was detected in 2,138 (43%) patients. Multivariable LASSO regression revealed that age, female gender, diabetes mellitus, previous MI, and left ventricular ejection fraction were independently associated with AVSc. All-cause mortality (adjusted hazard ratio: 1.29, 95%CI: 1.05–1.58) was significantly higher in AVSc than in non-AVSc patients. Conclusions: AVSc is frequently detected in high-risk CAD patients and is associated with long-term mortality. Our findings corroborate the hypothesis that AVSc is an underestimated marker of systemic cardiovascular risk. Thus, AVSc detection may be used to improve long-term risk stratification of high-risk CAD patients.

【 授权许可】

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