Circulating Proprotein Convertase Subtilisin/Kexin Type 9 Levels and Cardiometabolic Risk Factors: A Population-Based Cohort Study

Frontiers in Cardiovascular Medicine

article

Jie Shi¹  Xiaoyong Li¹  Weiwei Zhang¹  Yixin Niu¹  Ning Lin¹  Hongmei Zhang¹  Guang Ning²  Jiangao Fan³  Li Qin¹  Qing Su¹  Zhen Yang¹ 

[1] Department of Endocrinology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine;Department of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Institute of Endocrinology and Metabolism, Shanghai Jiao Tong University School of Medicine;Shanghai Key Laboratory of Children's Digestion and Nutrition, Department of Gastroenterology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine

关键词: proprotein convertase subtilisin kexin type 9;    dyslipidemia;    hypertension;    type 2 diabetes;    metabolic syndrome;    cardiometabolic risk factors;   

DOI  :  10.3389/fcvm.2021.664583

学科分类：地球科学(综合)

来源: Frontiers

【 摘 要 】

Aims: To evaluate the prospective association of circulating PCSK9 levels with the cardiometabolic risk profiles (high LDL-cholesterol, high triglycerides, low HDL-cholesterol, hypertension, type 2 diabetes, and metabolic syndrome). Methods: A population-based prospective study was conducted among 7,104 Chinese individuals (age 56.2 ± 7.5 years; 32.0% men). Circulating PCSK9 levels were measured using ELISA. Results: Circulating PCSK9 levels were higher in women than men (286.7 ± 90.1 vs. 276.1 ± 86.4 ng/ml, p 0.1). Conclusions: Elevated circulating PCSK9 was significantly associated with cardiometabolic risk factors and independently contributed to the prediction of cardiometabolic risks in women.

【 授权许可】

CC BY