Outcomes of Patients With ST-Segment Elevation Myocardial Infarction Admitted During COVID-19 Pandemic Lockdown in Germany – Results of a Single Center Prospective Cohort Study

Frontiers in Cardiovascular Medicine

article

Manuel Rattka¹  Lina Stuhler¹  Claudia Winsauer¹  Jens Dreyhaupt²  Kevin Thiessen¹  Michael Baumhardt¹  Sinisa Markovic¹  Wolfgang Rottbauer¹  Armin Imhof¹ 

[1] Clinic for Internal Medicine II, University Hospital Ulm - Medical Center;Institute of Epidemiology and Medical Biometry, Ulm University

关键词: COVID-19;    STEMI;    myocardial infarction;    lockdown;    outcome;    epidemiology;    Germany;   

DOI  :  10.3389/fcvm.2021.638954

学科分类：地球科学(综合)

来源: Frontiers

【 摘 要 】

Objective: Since the outbreak of the COVID-19 pandemic, healthcare professionals reported declining numbers of patients admitted with ST-segment myocardial infarction (STEMI) associated with increased in-hospital morbidity and mortality. However, the effect of lockdown on outcomes of STEMI patients admitted during the COVID-19 crisis has not been prospectively evaluated. Methods: A prospective, observational study on STEMI patients admitted to our tertiary care center during the COVID-19 pandemic was conducted. Outcomes of patients admitted during lockdown were compared to those patients admitted before and after pandemic-related lockdown. Results: A total of 147 patients were enrolled in our study, including 57 patients in the pre-lockdown group (November 1, 2019 to March 20, 2020), 16 patients in the lockdown group (March 21 to April 19, 2020), and 74 patients in the post-lockdown group (April 20 to September 30, 2020). Patients admitted during lockdown had significantly longer time to first medical contact, longer door-to-needle-time, higher serum troponin T levels, worse left ventricular end-diastolic pressure, and higher need for circulatory support. After a median follow-up of 142 days, survival was significantly worse in STEMI patients of the lockdown group (log-rank: p = 0.0035). Conclusions: This is the first prospective study on outcomes of STEMI patients admitted during public lockdown amid the COVID-19 pandemic. Our results suggest that lockdown might deteriorate outcomes of STEMI patients. Public health strategies to constrain spread of COVID-19, such as lockdown, have to be accompanied by distinct public instructions to ensure timely medical care in acute diseases such as STEMI.

【 授权许可】

CC BY