Case Report: Isolated and Focal Non-necrotizing Granulomatous Inflammation of Mitral Valves: A Report of Two Cases

Frontiers in Cardiovascular Medicine

article

Simona Pichler Sekulic¹  Miroslav Sekulic¹ 

[1] Department of Pathology and Cell Biology, Columbia University Irving Medical Center

关键词: cardiac valves;    non-necrotizing granuloma;    mitral valve;    prolapse;    regurgitation;   

DOI  :  10.3389/fcvm.2021.615707

学科分类：地球科学(综合)

来源: Frontiers

【 摘 要 】

Cardiac valve inflammation is seen in the setting of autoimmune or infectious processes, and rarely is valvulitis characterized by granulomatous inflammation. We present two patients who underwent surgical repair of prolapsing/regurgitating mitral valves. Excised valve tissue in both cases revealed commonly encountered nodular fibrosis and calcification, however each also revealed an isolated focus of non-necrotizing granulomatous inflammation. Typical implicating etiologies for non-necrotizing granulomatous inflammation were not present for either patient based on clinical history, or radiologic and laboratory data. In a review of 1048 cardiac valves excised at our institution, the finding of non-necrotizing granulomatous inflammation was seen in only the two described cases (prevalence of 0.19%). The description of non-necrotizing granulomatous inflammation within cardiac valves is limited in the literature, and the significance of the detailed isolated and incidental finding is unclear and requiring further investigation.

【 授权许可】

CC BY